In 2014-15 a total of $82,000 of research grants have been awarded to PANDAS/PANS research by PANDAS Network!
>$40,000 gifted to USF Dr. Tanya Murphy epigenetic research.
The USF clinic is studying possible epigenetic markers in PANDAS children. Antibody targeting of brain structures are thought to be a core pathology issue in PANDAS. Finding an immune based mechanism within immune genes is important research which will advance treatment.
>MGH $30,000 gifted by the Gold-Seelig family thru PANDASnetwork research donation fund.
A fund has been established for future research projects with the MGH PANDAS clinic.
>Tonsil study shows autoimmune inflammation present in PANDAS children
A $5,000 Research Assistance Grant helped to fund the recently published tonsil study, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus Immunology: A Pilot Study, by Drs. Beth Latimer, Neurology and Earl Harley, ENT (Georgetown University). This study shows PANDAS children have significant autoimmune induced inflammation. Two more papers will be published soon showing the kids reaction post-surgery and IVIG treatment.
>USF to research immune dysregulation in PANDAS children
A $4,000 Research Assistance Grant has been awarded to Dr. Tanya Murphy. Over a one year period, she will investigate monocyte activation in PANDAS patients in the USF Clinic. Monocytes play a central role in directing the immune system’s response to infection. Understanding the role of infection and immunological responses in PANDAS will help provide insight into a potential cause of disease, as well as, specific tools for diagnosis and treatment.
More specifically, Murphy will investigate TLR/CD14 pathways that are an integral to monocyte activation. Understanding the role of this pathway in PANDAS may help direct the search for gene targets because studies in this pathway have shown that TLR gene variants can influence susceptibility to infection and illness.
>Stanford Clinic to perform local sertotype strep testing
$3,000 has been gifted by local PANDAS Network families to be used especially for serotype strep testing in local communities. The hope is to test the positive strep swabs of PANDAS children who have a new onset or re-exacerbate in hopes of identifying the “strep type” that may be causing PANDAS. Although strep experts believe any type of strep can cause PANDAS identifying the particular serotype has long been a desire of parents.
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