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Research, Articles, Case Studies, & Reports

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Research, Articles, Case Studies, & Reports

Pandas Network Collected Research

2018 PANDAS Network State of Our Children Survey Results: A Precursor to the PN Patient Registry 
(PANDAS Network)
Results

2011 & 2015 Map of Cases 
(PANDAS Network)
PDF

Original Case Histories 
(PANDAS Network)
PDF

Autoimmune & Family History  
(PANDAS Network)
PDF

Observations From 80 Stories 
(PANDAS Network)
PDF

Data from 200 PANDAS Cases
(PANDAS Network)
PDF

2020

Evaluation of the Cunningham Panel in Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS) and Pediatric Acute-onset Neuropsychiatric Snydrome (PANS): Changes in Antineuronal Antibody Titers Parallel Changes in Patient Symptoms
(Craig Shimasaki, Richard E. Frye, Rosario Trifiletti, Michael Cooperstock, Gary Kaplan, Isaac Melamed, Rosalie Greenberg, Amiram Katz, Eric Fier, David Kem, David Traver, Tania Dempsey, M. Elizabeth Latimer, Amy Cross, Joshua P. Dunn, Rebecca Bentley, Kathy Alvarez, Sean Reim, James Appleman. January 2020)
Article

Learn more about the Cunningham Panel here

Study May Explain How Infections Reduce Autism Symptoms
(Anne Tafton. Neuroscience News. January 2020)
Article

 

2019

 Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue
(Anand Padmananbhan, Laura Connelly-Smith, Nicloe Aqui, Rasheed A. Balogun, Reinhard Klingel, Erin Meyer, Huy P. Pham, Jennifer Schneiderman, Volker Witt, Yanyun Wu, Nicold D. Zantek, Nancy M. Dunbar. Journal of Clinical Apheresis. 2019)
PDF

Harmful Bacteria Masquerade as Red Blood Cells to Evade the Immune System
(Katherine J. Wu. Smithsonian.com. December 2019)
Article

Focus on Cardiologic Findings in 30 Children with PANS/PANDAS: An Italian Single-Center Observational Study
(Murciano M, Biancone DM, Capata G, Tristano I, Martucci V, Guido VA, Anaclerio S, Loffredo L, Zicari AM, Duse M, Spalice A. Frontiers in Pediatrics. October 2019)
Article

Emergence of dominant toxigenic M1T1 Streptococcus pyogenes cone during increased scarlet fever activity in England: a population-based molecular epidemilogical study
(Nicola N Lynskey, PhD, Elita Jauneikaite, PhD, Ho Kwong Li, MBBS, Xiangyun Zhi, PhD, Claire E Turner, PhD, Mia Mosavie, MSc, et al. The Lancet. September 2019)
Article

How strep throat may spark OCD and anxiety in some kids
(Rachel Zamzow. Science News. August 2019)
Article

PANDAS: What Nurses Need to Know
(Melerine, Chelsea BSN; Ledet, Linda M. DNS, APRN, PMHCN-BC. Nursing 2019. August 2019)
Article

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients
(Gonca Gul Celik, Dedem Arslan Tas, Aysegul Yolga Tahiroglu, Eren Erken, Gulsah Seydaoglu, perihan Cam Ray, Ayse Avci. Arch Neuropsychiatry.  2019)
PDF

A Pediatric Infectious Disease Perspective on Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute-onset Neuropsychiatric Syndrome
(Wald, Ellen R.  The Pediatric Infectious Disease Journal 2019)
Article

What Parents Should Know About Infections and Mental Health
(Odelya Gertel Kraybill Ph.D. Psychology Today. June 2019)
Article

PANDAS: What Occupational Therapy Practitioners Should Know
(Barbara B. Demchick and Kate Eglseder. The American Occupational Therapy Association, Inc. June 2019)
Article

Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study
(Clara Westwell-Roper, Kyle A. Williams, Jack Samuels, O. Joseph Bienvenu, Bernadette Cullen, Fernando S. Goes, Marco A. Grados, Daniel Geller, Benjamin D. Greenberg, James A. Knowles, Janice Krasnow, Nicole C. McLaughlin, Paul Nestadt, Yin-Yao Shugart, Gerald Nestadt, and S. Evelyn Stewart. Journal of Child and Adolescent Psychopharmacology. June 2019)
Full Paper

Establishing a Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic: Baseline Clinical Features of the Pediatric Acute-Onset Neuropsychiatric Syndrome Cohort at Karolinska Institutet
(Caroline Gromark, Robert A. Harris, Ronny Wickstrom, AnnaCarin Horne, Maria Silverberg-Morse, Eva Serlachius, and David Mataix-Cols. Journal of Child and Adolescent Psychopharmacology. June 2019)
Full Paper

Clinical-Serological Characterization and Treatment Outcome of a Large Cohort of Italian Children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute Neuropsychiatric Syndrome
(Gemma Lepri, Donato Rigante, Silvia Bellando Randone, Antonella Meini, Alessandra Ferrari, Giusyda Tarantino, Madeleine W Cunningham, Fernanda Falcini. Journal of Child and Adolescent Psychopharmacology. May 2019)
Abstract

PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol
(Alessandra Gamucci, Sara Uccella, Lucia Sciarretta, Maria D'Apruzzo, Maria Grazia Calevo, Maria Margherita Mancardi, Edvige Veneselli, and Elisa De Grandis. Journal of Child and Adolescent Psychopharmacology. May 2019)
Article

Infections and Drugs to Treat Them Tied to Eating Disorders in Teens
(Diana Kwon. Scientific American. May 2019)
Article

PANDAS/PANS in Childhood: Controversies and Evidence
(Wilbur C, Bitnun A, Kronenberg S, Lax RM, Levy DM, Logan WJ, Shouldice M, Yeh EA. Paediatric Child Health. May 2019)
Abstract

The impact of attention deficit hyperactivity disorder in obsessive-compulsive disorder subjects [955 adults with OCD, 13.7% incidence of traits as pediatric onset with rheumatic fever](Thiago Blanco-Vieira, Matheus Santos, Ygor A. Ferrao, Albina R. Torres, Euripedes C. Miguel, Michael H. Bloch, James F. Leckman, Maria C. do Rosario. Depression and Anxiety. April 2019)
Abstract

Autoimmune Diseases and Psychotic Disorders
(Rose Jesppesen and Michael Eriksen Benros. Frontiers in Psychiatry. March 2019)
PDF

Immunoglobulin A Dysgammaglobulinemia is Associated with Pediatric-Onset Obsessive-Compulsive Disorder
(Kyle Williams, Leah Shorser-Gentile, Suraj Sarvode Mothi, Noah Berman, Mark Pasternack, Daniel Geller, and Jolan Walter.  Journal of Child and Adolescent Psychopharmacology. March 2019)
Abstract

Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum
(Luciana Frick PhD, Maximiliano Rapanelli PhD, Kantiya Jindachomthong BS, Paul Grant MD, James F. Leckman MD, PhD, Susan Swedo MD, Kyle Williams MD, PhD, Christopher Pittenger MD, PhD.  Brain, Behavior, and Immunity. March 2019)
PDF

PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol
(Alessandra Gamucci, Sara Uccella, Lucia Sciarretta, Maria D'Apruzzo, Maria Grazia Calevo, Maria Margherita Mancardi, Edvige Veneselli, Elisa De Grandis.  Journal of Child and Adolescent Psychopharmacology. February 2019)
Abstract

Neuropsychiatric Consequences of Childhood Group A Streptococcal Infection: A Systematic Review of Preclinical Models
(Santiago Mora, Elena Martin-Gonzolaz, Pilar Flores, Margarita Moreno.  Behavior, Brain, and Immunity. February 2019)
Abstract

ADHD and Addiction: What's the Connection? (may apply to undiagnosed young adults with prolonged symptoms of PANDAS/PANS)
(Walter Keenan, PhD, David Cohen, MD.  Drug Rehab Patient Advocacy Group. February 2019)
Article

Admission diagnoses of patients later diagnosed with autoimmune encephalitis
(Annette Baumgartner, Sebastian Rauer, Tilman Hottenrott, Frank Leypoldt, Friederike Ufer, Harald Hegen, Harald Pruss, Jan Lewerenz, Florian Deisenhammer, Oliver Stich.  Journal of Neurology. January  2019)
Abstract

2018

Treatment of PANDAS and PANS: a systemic review
(Sofia Sigra, Eva Hesselmark, Susanne Bejerot.  Neuroscience and Biobehaviorlal Reviews. October 2018)
Full Paper

Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS): Clinical Manifestations, IVIG Treatment Outcomes, Results from a Cohort of Italian Patients
(Piero Pavone, Raffaele Falsaperia, Francesco Nicita, Andreana Zecchini, Chiari Battaglia, Alberto Spalice, Lucia Iozzi, Enrico Parano, Giovanna Vitaliti, Alberto Verrotti, Vincenzo Belcastro, Sung Yoon Cho, Dong-Kyu Jin, Salvatore Savasta.  Neuropsychiatry (London). 2018)
PDF

The Diagnostic Value of Serological Studies in Pediatric Patients with Acute Mycoplasma Pneumoniae Infection
(Lin LJ, Chang FC, Chi H, Jim WT, Tsung-Ning Huang D, Kung YH, Chiu NC, Chang L. Journal of Microbiology, Immunology, and Infection. September 2018)
Abstract

New Research Investigates How PANDAS Affects the Brain, and How One Treatment May Work: Brain, Behavior, & Immunity
(Christ Pittenger, MD, PhD. OCD Newsletter Summer 2018)
Article

An Atypical Presentation of Pediatric Acute Neuropsychiatric Syndrome Responding to Plasmapheresis Treatment
(Drew H. Barzman, Hannah Jackson, Umesh Singh, Marcus Griffey, Michael Sorter, Jonathan A. Bernstein. Case Rep Psychiatry. June 2018)
Abstract

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients
(Gonca Gul Celik, Didem Arslan Tas, Aysegul Yolga Tahiroglu, Eren Erken, Gulsah Seydaoglu, Perihan Cam Ray, Ayse Avci. Arch. Neuropsychiatry.  2018)
PDF

European Advocacy Organizations Response to PANDAS/PANS Article
(Gerland Gunilla, Mogyorosi-Post Anita, Cafferky Karen, Galardini Giuliana, Granli Kristin, Tuckey Georgia. October 2018)
PDF

Family Impacts Reported By Parents Raising Children With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
(Marcey Mettica, B.S., M.S)
Dissertation PDF

2017

Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population
(Denise Calaprice, Janice Tona, and Tanya K. Murphy.Journal of Child and Adolescent Psychopharmacology. September 2017.)
Paper

Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome
(Swedo Susan E., Frankovich Jennifer, and Murphy Tanya K.. Journal of Child and Adolescent Psychopharmacology. July 2017)
Paper

Clinical Management of PANS: Part I–Psychiatric and Behavioral Interventions
(Thienemann Margo, Murphy Tanya, Leckman James, Shaw Richard, Williams Kyle, Kapphahn Cynthia, Frankovich Jennifer, Geller Daniel, Bernstein Gail, Chang Kiki, Elia Josephine, and Swedo Susan. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Full Paper

Clinical Management of PANS: Part II—Use of Immunomodulatory Therapies
(Frankovich Jennifer, Swedo Susan, Murphy Tanya, Dale Russell C., Agalliu Dritan, Williams Kyle, Daines Michael, Hornig Mady, Chugani Harry, Sanger Terence, Muscal Eyal, Pasternack Mark, Cooperstock Michael, Gans Hayley, Zhang Yujuan, Cunningham Madeleine, Bernstein Gail, Bromberg Reuven, Willett Theresa, Brown Kayla, Farhadian Bahare, Chang Kiki, Geller Daniel, Hernandez Joseph, Sherr Janell, Shaw Richard, Latimer Elizabeth, Leckman James, Thienemann Margo, and PANS/PANDAS Consortium. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Full Paper

Clinical Management of PANS: Part III—Treatment and Prevention of Infections
Cooperstock Michael S., Swedo Susan E., Pasternack Mark S., Murphy Tanya K., and for the PANS PANDAS Consortium. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Full Paper

Pediatric Acute-Onset Neuropsychiatric Syndrome Response to Oral Corticosteroid Bursts: An Observational Study of Patients in an Academic Community-Based PANS Clinic
(Brown Kayla, Farmer Cristan, Farhadian Bahare, Hernandez Joseph, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Abstract

Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study
(Spartz Ellen J., Freeman G. Mark Jr., Brown Kayla, Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Abstract

Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Observational Study of Patients Followed by an Academic Community-Based Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic
(Brown Kayla D., Farmer Cristan, Freeman G. Mark Jr., Spartz Ellen J., Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Abstract

A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive-Compulsive Disorder.
(Murphy Tanya K., Brennan , Johnco , Parker-Athill , Miladinovic , Storch , Lewin. Journal of Child and Adolescent Psychopharmacology. July 2017.)
Abstract

Association of Streptococcal Throat Infection With Mental Disorders: Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study
(Sonja Orlovska, Claus Høstrup Vestergaard,  Bodil Hammer Bech. JAMA Psychiatry. July 2017.)
Full Paper

Cognitive Behavioral Therapy And Acceptance And Commitment Therapy As Augmentation Treatment For (Pandas): A Case Report
(A.Pozza - European Psychiatry - 2017)
Abstract

Hello from the Other Side: How Autoantibodies Circumvent the Blood–Brain Barrier in Autoimmune Encephalitis
(Maryann P. Platt, Dritan Agalliu, Tyler Cutforth - Frontiers in Immunology)
Full Paper

Palatal Petechiae in the Absence of Group A Streptococcus in Pediatric Patients with Acute-Onset Neuropsychiatric Deterioration: A Cohort Study
(Mahony Talia, Sidell Douglas, Gans Hayley, Cooperstock Michael, Brown Kayla, Cheung Joanne M, Farhadian Bahare, Gustafson Melissa, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. April 2017)
Abstract

Impact of PANS and PANDAS Exacerbations on Occupational Performance: A Mixed-Methods Study
(Janice Trigilio Tona; Sutanuka Bhattacharjya; Denise Calaprice. American Journal of Occupational Therapy. March 2017.)
Abstract

Prospective Longitudinal Analysis of Immune Responses in Pediatric Subjects After Pharyngeal Acquisition of Group A Streptococci
(Nicholas D. Hysmith, Edward L. Kaplan, P. Patrick Cleary, Dwight R. Johnson, Thomas A. Penfound, James B. Dale. Journal of Pediatric Infectious Disease Society. February 2017)
Full Paper

Improvement Of Psychiatric Symptoms In Youth Following Resolution Of Sinusitis
Talia Mahony, Douglas Sidell, Hayley Gans, Kayla Brown, Bahare Farhadian, Melissa Gustafson, Janell Sherr, Margo Thienemann, Jennifer Frankovich (International Journal of Pediatric Otorhinolaryngology. January 2017.)
Full Paper

Hidden Invaders: Infections Can Trigger Immune Attacks On Kids’ Brains, Provoking Devastating Psychiatric Disorders
(Pamela Weintraub. Discover Magazine. April 2017)
article

2016

Vitamin D Deficiency in Obsessive-Compulsive Disorder Patients with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections: A Case Control Study
(Gonca Çeli̇k, Didem Taş, Ayşegül Tahi̇roğlu, Ayşe Avci, Bilgin Yüksel, Perihan Çam. Noro Psikiyatr Ars. March 2016.)
Paper

The Neuropsychological Profile Of Children With Basal Ganglia Encephalitis: A Case Series
(Pawela C, Brunsdon RK, Williams TA, Porter M, Dale RC, Mohammad SS. Developmental Medicine & Child Neurology. December 2016.)
Abstract

Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections
(Kyle A. Williams, MD, PhD, Susan E. Swedo, MD, Cristan A. Farmer, PhD, Heidi Grantz, LCSW, Paul J. Grant, MD, Precilla D’Souza, CRNP, Rebecca Hommer, MD, Liliya Katsovich, MA, Robert A. King, MD, James F. Leckman, MD, Phd. Journal of the American Academy of Child & Adolescent Psychiatry. October 2016.)
Article

Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
Gaughan T ,Buckley A, Hommer R, Grant P, Williams K, Leckman JF, Swedo SE. Journal of Clinical Sleep Medicine. July 2016.)
Abstract

Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies
(Chiara Spinello, Giovanni Laviola and Simone Macrì. Frontiers in Neuroscience. June 2016.)
Article

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)
(Graziella Orefici, PhD, Francesco Cardona, MD, Carol J. Cox, PhD, and Madeleine W. Cunningham, PhD. Excerpt from: Streptococcus Pyogenes Basic Biology to Clinical Manifestations, University of Oklahoma Health Sciences Center. February 2016.)
Excerpt

2015

Therapeutic Plasma Apheresis as a Treatment for 35 Severely Ill Children and Adolescents with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections
(M. Elizabeth Latimer, Nathan L'Etoile, Jakob Seidlitz, Susan E. Swedo.  Journal of Child and Adolescent Psychopharmacology. February 2015.)
Abstract

Use of Intravenous Immunoglobulin in the Treatment of Twelve Youths with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
(Miro Kovacevic, Paul Grant, Susan E. Swedo Journal of Child and Adolescent Psychopharmacology. Febrary 2015)
Abstract

Antineuronal Antibodies in a Heterogeneous Group of Youth and Young Adults with Tics and Obsessive-Compulsive Disorder
(Carol J. Cox, Amir J. Zuccolo, Erica V. Edwards, Adita Mascaro-Blanco, Kathy Alvarez, Julie Stoner, Kiki Chang, Madeleine W. Cunningham. Journal of Child and Adolescent Psychopharmacology. February 2015.)
Abstract

Clinical Presentation of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections in Research and Community Settings
(Susan E. Swedo, Jakob Seidlitz, Miro Kovacevic, M. Elizabeth Latimer, Rebecca Hommer, Lorraine Lougee, Paul Grant. Journal of Child and Adolescent Psychopharmacology. 2015)
Abstract

Five Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome of Differing Etiologies
Jennifer Frankovich, Margo Thienemann, Sonal Rana, Kiki Chang. Journal of Child and Adolescent Psychopharmacology. 2015.)
Abstract

Multidisciplinary Clinic Dedicated to Treating Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome: Presenting Characteristics of the First 47 Consecutive Patients
(Jennifer Frankovich, Margo Thienemann, Jennifer Pearlstein, Amber Crable, Kayla Brown, Kiki Chang Journal of Child and Adolescent Psychopharmacology. February 2015)
Abstract

Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells
(Thamotharampillai Dileepan, Erica D. Smith, Daniel Knowland, Martin Hsu, Maryann Platt, Peter Bittner-Eddy, Brenda Cohen, Peter Southern, Elizabeth Latimer, Earl Harley Dritan Agalliu. and P. Patrick Cleary. Journal of Clinical Investigation. December 2015.)
Article

Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells
Presented by Dr. Dritan Agalliu and Dr. Patrick Cleary
Video

Detection Of Anti-streptococcal, Antienolase, And Anti-neural Antibodies In Subjects With Early-onset Psychiatric Disorders
(Nicolini H, López Y, Genis-Mendoza AD, Manrique V, Lopez-Canovas L, Niubo E, Hernández L, Bobes MA, Riverón AM, López-Casamichana M, Flores J, Lanzagorta N, De la Fuente-Sandoval C, Santana D.  Actas Esp Psiquiatr. March 2015.)
Abstract

Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus Immunology: A Pilot Study
(Walls A, Cubangbang M, Wang H, Raiji M, Knight J, Steehler M, Latimer E, Harley EH Jr.. Otolaryngology Head and Neck Surgery. April 2015.)
Abstract

Characterization of B-Cells in tonsils of patients diagnosed with pediatric autoimmune neuropsychiatric disorder associated streptococcus
(Walls A, Dermody S, Kumaran R, Krishnan N, Harley EH Jr.. International Journal of  Pediatric Otorhinolaryngology. November 2015.)
PDF

The Role of Tonsillectomy in the Treatment of Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS)
Daniel Demesh, MD; Jordan M. Virbalas, MD; John P. Bent, MD (JAMA Otolaryngology Head Neck Surgery. March 2015.)
Case Report

Sydenham Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Management in Resource-Poor Countries
(Kathleen G. Walker, Petrus J. de Vries, Dan J. Stein, and Jo M. Wilmshurst. Journal of Child Neurology. 2015.
Article

 

2014

Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference
(Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W. Cunningham, M. Elizabeth Latimer, Tanya K. Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, Susan E. Swedo, From the PANS Collaborative Consortium. Journal of Child and Adolescent Psychopharmacology. 2014.)
Abstract

Disordered Eating and Food Restrictions in Children with PANDAS/PANS
(Megan D. Toufexis, Rebecca Hommer, Diana M. Gerardi, Paul Grant, Leah Rothschild, Precilla D'Souza, Kyle Williams, James Leckman, Susan E. Swedo, Tanya K. Murphy Journal of Child and Adolescent Psychopharmacology. 2014.)
Abstract

Cefdinir for Recent-Onset Pediatric Neuropsychiatric Disorders: A Pilot Randomized Trial
Tanya K. Murphy, E. Carla Parker-Athill, Adam B. Lewin, Eric A. Storch, P. Jane Mutch. Journal of Child and Adolescent Psychopharmacology. 2014.)
Abstract

Characterization of the Pediatric Acute-Onset Neuropsychiatric Syndrome Phenotype
(Tanya K. Murphy, Priyal D. Patel, Joseph F. McGuire, Allison Kennel, P. Jane Mutch, E. Carla Parker-Athill, Camille E. Hanks, Adam B. Lewin, Eric A. Storch, Megan D. Toufexis, Gul H. Dadlani, Carina A. Rodriguez Journal of Child and Adolescent Psychopharmacology. 2014.)
Abstract

PANDAS and Comorbid Kleine–Levin Syndrome
(Diana M. Gerardi, Joseph Casadonte, Priyal Patel, Tanya K. Murphy. Journal of Child and Adolescent Psychopharmacology. 2014.)
First Page

Pediatric Inflammatory Brain Diseases: A Diagnostic Approach
(Van Mater, Heather. Current Opinion in Rheumatology. September 2014.)
Abstract

Post-infectious Autoimmune Disorders: Sydenham’s Chorea, PANDAS and Beyond
(Kyle A. Williams, Susan E. Swedo.  Elsevier Science Direct. 2014)
Abstract

Evaluation of Basal Ganglia and Thalamic Inflammation in Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection and Tourette Syndrome-A Positron Emission Tomographic (PET) Study Using 11C-[R]-PK11195
(Ajay Kumar, MD, PhD, DNB; Mitchel T. Williams, MD; Harry T. Chugani, MD.  Journal of Child Neurology. 2014)
Abstract

Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats
(Dafna Lotan, Itai Benhar, Kathy Alvarez, Adita Mascaro-Blanco, Lior Brimberg, Dan Frenkel, Madeleine W. Cunningham, Daphna Joel.  Elsevier Science Direct. 2014.)
Abstract

The Curious Case Of The “Inseparable Child”
(Praveen Navkhare, Gurvinder Kalra.  Indian Journal of Psychiatry. 2014.)
Full Paper

A Link Between Perianal Strep and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection (PANDAS)
(Megan Toufexis, D.O.; Caroline DeOleo, M.D.; Josephine Elia, M.D.; Tanya K. Murphy, M.D.. Journal of Neuropsychiatry & Clinical Neurosciences. 2014.)
Full Paper

2013

Periodic Fever and Hyperimmunoglobulin D Syndrome in a Boy with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Group A β-Hemolytic Streptococcus
(Perihan Cam Ray, Didem Arslan Tas, Gonca Gul Celik, Ayşegul Yolga Tahiroglu, Ayşe Avci, and Eren Erken Journal of Child and Adolescent Psychopharmacology. 2013.)
First Page

From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)
Susan E. Swedo, James F. Leckman, Noel R. Rose  (Pediatrics and Therapeutics-2013)
Full PDF

A Case Report of Obsessive-Compulsive Disorder Following Acute Disseminated Encephalomyelitis
(Katherine E. Muir, Katherine S. McKenney, Mary B. Connolly, S. Evelyn Stewart.  AAP Gateway. 2013.)
Abstract

Dopamine Receptor Autoantibodies Correlate with Symptoms in Sydenham's Chorea
(Hilla Ben-Pazi, Julie A. Stoner, and Madeleine W. Cunningham. PLoS One. 2013.)
Full Paper

Guidelines on the Use of Therapeutic Apheresis in Clinical Practice—Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Sixth Special Issue
(Joseph Schwartz, Jeffrey L. Winters,  Anand Padmanabhan, Rasheed A. Balogun,  Meghan Delaney, Michael L. Linenberger, Zbigniew M. Szczepiork.  Journal for Apheresis. 2013)
Full Paper

Clinical Factors Associated with PANDAS
Tanya K. Murphy, Eric A. Storch, Adam B. Lewin,Paula J. Edge, Wayne K. Goodman. Journal of Pediatrics.  February 2003.)
Full Paper

Autoimmune Encephalitis - History & Current Knowledge
(Finn E. Somnier, M.D., D. Sc. (Med.), Department of Clinical Biochemistry, Immunology and Genetics, Staten’s Serum Institute, Copenhagen, Denmark.  June 2013.)
Full PDF

2010-2012

Passive Transfer Of Streptococcus-induced Antibodies Reproduces Behavioral Disturbances In A Mouse Model Of Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection.
(Yaddanapudi K1, Hornig M, Serge R, De Miranda J, Baghban A, Villar G, Lipkin WI.  Molecular Psychiatry.  2009)
Abstract

The Relationship Between Group A Beta Hemolytic Streptococcal Infection And Psychiatric Symptoms: A Pilot Study
(Cengel-Kültür SE, Cöp E, Kara A, Cengiz AB, Uludağ AK, Unal F.  Turkish Journal of Pediatrics. 2009.)
Abstract

Executive and Attention Functioning Among Children in the PANDAS Subgroup
Matthew E. Hirschtritt, Christopher J. Hammond, David Luckenbaugh, Jason Buhle, Audrey E. Thurm, B. J. Casey, and Susan E. Swedo.  Child Neuropsychology. July 2008.)
Full Article

Mycoplasma pneumoniae infection and obsessive-compulsive disease: a case report
(Ercan TE, Ercan G, Severge B, Arpaozu M, Karasu G.  Journal of Child Neurology. March 2008)
Abstract

Challenges in the Identification and Treatment of PANDAS: A Case Series
(Abdul Azim Mabrouk and Valsamma Eapen.  Journal of Tropical Pediatrics. 2008)
Full PDF

Therapeutic Response to Plasmapheresis in Four Cases with Obsessive-Compulsive Disorder and Tic Disorder Triggered by Streptococcal Infections
( Lütfullah BEŞİROĞLU, Mehmet Yücel AĞARGÜN, Özgür ÖZBEBİT, Mehmet SÖZEN, İmdat DİLEK, Mustafa GÜLEÇ.  Turkish Journal of Psychology. 2007)
Full PDF

Certain Eating Disorders May Be a Neuropsychiatric Manifestation of PANDAS: Case Report
(Cynthia V. Calkin, MD, Carlo G. Carandang, MD ABPN.  Journal of the Canadian Academy of Child and Adolescent Psychiatry 2007.)
Full Article

Relationship Of Movements And Behaviors To Group A Streptococcus Infections In Elementary School Children
(Murphy TK, Snider LA, Mutch PJ, Harden E, Zaytoun A, Edge PJ, Storch EA, Yang MC, Mann G, Goodman WK, Swedo SE.  Biological Psychiatry. 2007.)
Abstract

Group A Streptococcus and its Antibiotic Resistance
(D Passàli, M Lauriello, GC Passàli, FM Passàli, L Bellussi. Acta Otorhinolaryngol Ital. February 2007.)
Full Article

Selective Serotonin Reuptake Inhibitor-Induced Behavioral Activation in the PANDAS Subtype
(Tanya K. Murphy, MD, Eric A. Storch, PhD, and Melissa S. Strawser, BA.  Primary Psychiatry. 2006.)
Article

Antibody-mediated Neuronal Cell Signaling In Behavior And Movement Disorders
(Christine A. Kirvan a , Susan E. Swedo b , Lisa A. Snider b , Madeleine W. Cunningham.  Journal of Neuroimmunology. 2006)
Full PDF

Selective Serotonin Reuptake Inhibitor-Induced Behavioral Activation in the PANDAS Subtype
(Tanya K. Murphy, MD, Eric A. Storch, PhD, and Melissa S. Strawser, BA.  Primary Psychiatry. 2006.)
Full PDF

Strep and Urinary Frequency: Is There a Connection?
(Christina Kim, MD, Steven G. Docimo, MD, Kathleen McKay, PhD.  NE Section of the American Urological Association. 2006.)
Article

Viable Group A Streptococci in Macrophages during Acute Soft Tissue Infection
(Pontus Thulin, Linda Johansson, Donald E Low, Bing S Gan,Malak Kotb, Allison McGeer, Anna Norrby-Teglund.  PLOS Medicine. January 2006)
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Antibiotic Prophylaxis With Azithromycin Or Penicillin For Childhood-onset Neuropsychiatric Disorders
(Snider LA, Lougee L, Slattery M, Grant P, Swedo SE. Biological Psychiatry.  April 2005)
Abstract

Evaluation of Poststreptococcal Illness
(Ricardo G. Hahn, M.D., Lynda M. Knox, Ph.D., And Todd A. Forman, M.D., M.S.Ed. American Family Physician.  May 2005.)
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Encephalitis Lethargica Syndrome: 20 New Cases And Evidence Of Basal Ganglia Autoimmunity
(Russell C. Dale, Andrew J. Church, Robert A. H. Surtees, Andrew J. Lees, Jane E. Adcock, Brian Harding, Brian G. R. Neville, Gavin Giovannoni.  Brain. 2004)
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Pandas: Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections--an Uncommon, But Important Indication For Tonsillectomy.
(Heubi C, Shott SR. International Journal of Pediatric Otorhinolaryngology. August 2003.)
Abstract

Immune Response to Group A Streptococcal C5a Peptidase in Children: Implications for Vaccine Development
(Anita Shet Edward L. Kaplan Dwight R. Johnson P. Patrick Cleary.  Journal of Infectious Diseases. September 2003.)
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Tourette's Syndrome: A Cross Sectional Study To Examine The PANDAS Hypothesis
(A Church, R Dale, A Lees, G Giovannoni, and M Robertson.  Journal of Neurology Neurosurgery Psychiatry. 2003.)
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Autoimmunity And The Basal Ganglia: New Insights Into Old Diseases
( R.C. DALE.  QJMed. 2003.)
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Post-streptococcal autoimmune disorders of the central nervous system
(Lisa A. Snider and Susan E. Swedo. 2003.)
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Mimicry and Autoantibody-mediated Neuronal Cell Signaling in Sydenham Chorea
(Christine A. Kirvan, Susan E. Swedo, Janet S. Heuser, Madeleine W. Cunningham.  Nature Medicine. 2003.)
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Pediatric Autoimmune Neuropsychiatric Disorders and Streptococcal Infections: Role Of Otolaryngologist
(Orvidas LJ, Slattery MJ., Laryngoscope.  September 2001.)
Abstract

The Pandas Subgroup: Recognition And Treatment
(Swedo SE, Garvey M, Snider L, Hamilton C, Leonard HL.  CNS Spectrums. 2001.)
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PANDAS Variant and Body Dysmorphic Disorder
(Sanjay Mathew.  American Journal of Psychiatry. 2001)
Letter to Editor

Pathogenesis of Group A Streptococcal Infections
(Madeleine W. Cunningham.  Clinical Microbiology Review.  July 2000)
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MRI Assessment of Children With Obsessive-Compulsive Disorder or Tics Associated With Streptococcal Infection
(Jay N. Giedd, M.D., Judith L. Rapoport, M.D., Marjorie A. Garvey, M.D., Susan Perlmutter, M.D., and Susan E. Swedo, M.D..  American Journal of Psychology. 2000.)

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Therapeutic Plasma Exchange And Intravenous Immunoglobulin For Obsessive-compulsive Disorder And Tic Disorders In Childhood
(Perlmutter SJ, Leitman SF, Garvey MA, Hamburger S, Feldman E, Leonard HL, Swedo SE.  Lancet. 1999.)
Abstract

Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections: Clinical Description of the First 50 Cases
(Susan E. Swedo, M.D., Henrietta L. Leonard, M.D., Marjorie Garvey, M.D., Barbara Mittleman, M.D., Albert J. Allen, M.D., Ph.D., Susan Perlmutter, M.D., Lorraine Lougee, L.C.S.W., Sara Dow, B.A., Jason Zamkoff, B.A., and Billinda K. Dubbert, M.S.N..  American Journal of Psychiatry. March 1998)
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2010-2012

Lyme Disease and Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (Pandas): An Overview
(Hanna Rhee, Daniel J Camero. International Journal of General Medicine. 2012.)
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Behavioral, Pharmacological, And Immunological Abnormalities After Streptococcal Exposure: A Novel Rat Model Of Sydenham Chorea And Related Neuropsychiatric Disorders
(Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D. Neuropsychopharmacology. August 2012.)
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A Case Of Pandas With Kleine–levin Type Periodic Hypersomnia
(Abhijit Das, Ashalatha Radhakrishnan.  Sleep Medicine. 2012.)
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Neurocognitive Functioning in Youth With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcus
(Adam B. Lewin, Ph.D., A.B.P.P., Eric A. Storch, Ph.D., P. Jane Mutch, Ph.D., Tanya K. Murphy, M.D.. Journal of Neuropsychiatry Clinical Neuroscience. 2011.)
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Clinical Factors Associated with PANDAS
(Tanya K. Murphy, MD, Eric A. Storch, PhD, Adam B. Lewin, PhD., Paula J. Edge, BS., and Wayne K. Goodman, MD.  Journal of Pediatrics. 2011.)
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Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcus In Identical Siblings.
(Lewin AB, Storch EA, Murphy TK Journal of Neuropsychiatry Clinical Neuroscience. 2011.)
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Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS): An Indication For Tonsillectomy
(Alexander AA, Patel NJ, Southammakosane CA, Mortensen MM.  International Journal of Pediatric Otorhinolaryngology. 2011.)
Abstract

Maternal History of Autoimmune Disease in Children Presenting with Tics and/or Obsessive-Compulsive Disorder
(T.K. Murphy, E.A. Storch, A. Turner, J.M. Reid, J. Tan, A.B. Lewin. Journal of  Neuroimmunology. 2011.)
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The Immunobiology of Tourette’s Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward
(Tanya K. Murphy, Roger Kurlan,and James Leckman. Journal of Child and Adolescent Psychopharmacology. 2010.)
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Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): A Case Report
(Mona Srivastava, Ganesh Shankar, M.N.Tripathi.  Journal of Diagnostic and Clinical Research. November 2011.)
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Oral Inflammatory Process And General Health. Part 1: The Focal Infection And The Oral Inflammatory Lesion.
(Somma F, Castagnola R, Bollino D, Marigo L. European Review for Medical and Pharmacological Sciences.  December 2010)
Abstract

Oral Inflammatory Process And General Health. Part 2: How does the periapical inflammatory process compromise general health?
(Somma F, Castagnola R, Bollino D, Marigo L. European Review for Medical and Pharmacological Sciences.  January 2011)
Abstract