Maternal Autoimmune Disease and PANDAS



Does maternal autoimmune disease increase the likelihood of OCD, tics, and PANDAS occurring in children? According to Dr. Tanya Murphy, it does.

In the May 2011 edition of Clinical Psychiatry News, it states that maternal autoimmune disease occurs in 17.8% of mothers to kids with OCD and tics. In the PANDAS population, the percentage is even higher at 25%. That means as much as 25% of mothers of PANDAS children may suffer from an autoimmune disease themselves. Hashimoto’s thyroiditis was the most prevalant at 11.9%.  This connection was first noted in 2010 when the study Maternal history of autoimmune disease in children presenting with tics and/or obsessive-compulsive disorder was published. At the annual meeting of the American Neuropsychiatric Association, new additional information was also shared,

“In a second study Dr. Murphy presented at the meeting, she showed for the first time that elevated levels of soluble cluster of differentiation 14 (sCD14) are present at the same time as acute flares of neuropsychiatric symptoms in children with PANDAS. High levels of sCD14 are indicative of macrophage activation, a key component of innate immunity. “

Connections like this can be beneficial as in opens doors to possible future treatments options and further research. To view the entire article, please visit Clinical Psychiatry News.