Yale/Columbia Study Finds Harmful Auto Antibodies in PANDAS

See image of how PANDAS damages the blood brain barrier here Read the following research article here. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity(Jian Xu, PhD, Rong-Jian Liu, PhD, Shaylyn Fahey, BS, Luciana Frick, PhD, James Leckman, MD,PhD, Flora Vaccarino, MD, Ronald S. Duman, PhD, Kyle Williams, MD, PhD, Susan Swedo, MD, …

Diagnosis and Treatment Guidelines

JCAP 2017 Guidelines for treating PANS/PANDAS An expert panel has published guidelines for treatment of Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) and a subset of patients diagnosed with PANS Disorder Associated with Streptococcal Infection (PANDAS). The syndrome of sudden onset obsessive compulsive disorder and/or severe eating restrictions, and associated characteristic cognitive, behavioral or neurological symptoms, was first identified in the …

Basal Ganglia Encephalitis Caused by Strep – Proven

Th17 Lymphocytes Drive Vascular and Neuronal Deficits in a Mouse Model of Postinfectious Autoimmune Encephalitis (Maryann P. Platt, Kevin A. Bolding, Charlotte R. Wayne, Sarah Chaudhry, Tyler Cutforth, Kevin M. Franks, and Dritan Agalliu) Read abstract here Video discussing paper can be viewed here Group A Streptococcus Intranasal Infection Promotes CNS Infiltration by Streptococcal-specific Th17 Cells (Thamotharapillai Dileepan, Erica D. Smith, Daniel Knowland, Martin Hsu, Maryann …

Newly Published Survey of PANDAS-PANS

Newly Published Surveys of PANDAS-PANS 700+ #1 – PANS Syndrome Characteristics and Course The purpose of the present study was to characterize the global clinical picture and range of phenotypes of pediatric acute-onset neuropsychiatric syndrome (PANS) in a large sample… Download Survey #1 #2 – Treatment Results of 700 PANS Cases Download Survey #2

Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections  (Jennifer L. Chain, Kathy Alvarez, Adita Mascaro-Blanco, Sean Reim, Rebecca Bentley, Rebecca Hommer, Paul Grant, James F. Leckman, Ivana Kawikova, Kyle Williams, Julie A. Stoner, Susan E. Swedo, and Madeleine W. Cunningham . Front. Psychiatry. June 2020) Read full paper here Breakthrough …

Research in Action

Learn what is on the horizon of innovative PANDAS/PANS research. Journal of Clinical Investigation publishes a SIGNIFICANT STEP IN UNDERSTANDING THE MECHANISMS of PANDAS. Scientists investigated how Group A Strep Causes Autoimmune Reactivity, Breaks Down the Blood Brain Barrier (BBB), and then allows Autoantibodies Specific to Strep to Enter the BBB. CLICK HERE

2018 Harvard-MGH Survey

How Does Having a Child With PANS/PANDAS Affect Family Life? We are inviting you to take part in a 40-70-minute research study, conducted by the Massachusetts General Hospital and Harvard University, assessing the impact of the symptoms of PANS/PANDAS, Obsessive Compulsive Disorder, and other related conditions on family dynamics. This survey is completely anonymous, and will ask you questions regarding …