PANDAS/PANS Clinical and Scientific Research

PANDAS/PANS is a relatively new syndrome that is often missed in diagnosis; therefore, research into the disease is essential to raise awareness and improve outcomes for PANDAS/PANS patients and their families. Watch this video to learn how harmful autoantibodies and cytokines cause acute onset in children. This supports the premise that early treatment is absolutely necessary.

This video and the paper that it stems from is the result of $10+ million dollars foundational research from the NIMH, Yale, Columbia, and University of Oklahoma. This cutting-edge Columbia University Research will be published in a major journal in 2024/2025. Looking at the Brain of PANDAS and PANS Children

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The etiology of PANDAS/PANS grew from recognition of a 19th-century disorder called Sydenham’s chorea, where repeated infections with group A strep caused profound neurological and body movement abnormalities termed “chorea,” and to a lesser extent recognized psychological changes. In the 1990s, PANDAS/PANS was identified as a separate disease entity because of the more profound, acute and dramatic mental health changes that result from infections with group A strep. The current research that is being published in the U.S. and worldwide indicates that Sydenham’s chorea, PANDAS, and PANS are forms of post-infectious autoimmune encephalitis, basal ganglia encephalitis (BGE), meaning inflammation of the basal ganglia after an infection. 

This is one of the first renderings worldwide of how the blood vessels of the brain, that normally form a blood–brain barrier to prevent immune cells and antibodies from getting inside the brain, may be damaged due to peripheral inflammatory and immune processes arising after multiple group A strep infections. We see a similar process in Long COVID-19.

In summary, this is cutting-edge research in the area of neuro-psycho-immunology that addresses how the brain, mind, and immune system are affected by the disease and how they interconnect with one another. Our researchers and doctors persist because early diagnosis and treatment are showing promising outcomes and helping children live happy, healthy lives.

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