Dopamine-2-Receptor-Specific T Cells in Pediatric Psychiatric and Movement Disorders

A study from Clinical & Translative Immunology highlights the significance of immune dysregulation in pediatric psychiatric and movement disorders. Even though brain inflammatory processes are a hallmark of PANDAS/PANS – and have been furthermore linked to an autoimmune response in the absence of external antibodies, in which someone’s innate immune system mistakenly attacks their own… Continue reading Dopamine-2-Receptor-Specific T Cells in Pediatric Psychiatric and Movement Disorders

Autoantibody Biomarkers for Autoimmune Encephalitis in Sydenham Chorea and PANDAS

Autoantibodies in Basal Ganglia Encephalitis, Sydenham Chorea and PANDAS The Cunningham study sought to identify the role of anti-neuronal biomarkers (used as a group) to confirm acute disease in Sydenham Chorea (SC) and PANDAS. In doing so, the investigators attempted to further explain the disease mechanism contributing to SC and PANDAS. Participants were tested for … Continue reading Autoantibody Biomarkers for Autoimmune Encephalitis in Sydenham Chorea and PANDAS

Group A Strep S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Invasion

How Group A strep can evade the immune system surveillance Each year 500,000 people die worldwide from Group A strep. Much of how group A strep manages to outsmart the body’s defenses remains mysterious.  A newly recognized protein, S-protein, was discovered that allows the bacteria to “mimic” red blood cells and avoid surveillance by the… Continue reading Group A Strep S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Invasion

Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis

How autoantibodies circumvent the blood-brain barrier in autoimmune encephalitis Autoimmune Encephalitis creates problems with neurological and psychiatric function. The role of virus, bacteria and tumor creating AE onset has been identified but the immune mechanisms are not well understood.  The role of Group A strep in animal models of post-infectious basal ganglia encephalitis is newly… Continue reading Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis