Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis
How autoantibodies circumvent the blood-brain barrier in autoimmune encephalitis
Autoimmune Encephalitis creates problems with neurological and psychiatric function. The role of virus, bacteria and tumor creating AE onset has been identified but the immune mechanisms are not well understood. The role of Group A strep in animal models of post-infectious basal ganglia encephalitis is newly discovered and outlined as well.
Outlined in detail are the following:.
- proposed triggers for various autoimmune encephalopathies and their animal models;
- basic structural features of the BBB and how they differ among various CNS regions, a feature that likely underlies some regional aspects of autoimmune encephalitis pathogenesis;
- routes that antibodies and immune cells employ to enter the CNS; and
- therapeutic strategies that may either preserve or restore barrier function and thereby limit immune cell and autoantibody infiltration into the CNS
Autoimmune Encephalitis creates problems with neurological and psychiatric function.
Outlined in detail are the following:
21 April 2017https://www.frontiersin.org/articles/10.3389/fimmu.2017.00442/full