Large Scale Survey of Children with PANDAS/PANS

A Survey of Pediatric Acute-Onset Neuropsychiatric Syndrome Characteristics and Course Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population Factors Associated with Symptom Persistence in PANS: Part II—Presenting Features, Medical Comorbidities, and IVIG Treatment History Factors Associated with Symptom Persistence in PANS: Part I—Access to Care

Streptococcus and the Risk for Major Mental Disorders

Association of Streptococcal Throat Infection With Mental Disorders (Benros, JAMA Psychiatry, 2017) Risk of Major Mental Disorder after Severe Bacterial Infections in Children and Adolescents: A Nationwide Longitudinal Study (Hsu, Neuropsychobiology, 2022)

Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Many therapies are shown to improve immune function and can improve health outcomes in patients 56 randomized clinical trials with over 4,000 participants were analyzed to determine if various kinds of psychosocial therapies positively impact the immune system of patients who sought treatment for a variety of mental and physical problems. A large body of… Continue reading Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Patients with Abrupt Early-onset OCD due to PANS Tolerate Lower Doses of Antidepressants and Antipsychotics

PANS children tolerate lower doses of psychotropic medications This is the first published study of its kind measuring tolerability of psychiatric medications in PANS children.  It is a retrospective review of charts of 188 PANS patients (mean age 8.5 yrs) seen in the Stanford PANS clinic, were studied for side effects, and dose tolerance, as… Continue reading Patients with Abrupt Early-onset OCD due to PANS Tolerate Lower Doses of Antidepressants and Antipsychotics

Association of Primary Humoral Immunodeficiencies with Psychiatric Disorders & Suicidal Behavior & the Role of Autoimmune Diseases

A Swedish Database of 14 million individuals was studied to Discover the link between immune deficiency and mental health disorders A collaboration between a Harvard PANDAS researcher and the Karolinska Institute of Sweden was carried out.  Data was studied from more than 14 million individuals living in Sweden from January 1, 1973, through December 31,… Continue reading Association of Primary Humoral Immunodeficiencies with Psychiatric Disorders & Suicidal Behavior & the Role of Autoimmune Diseases

Immunological Causes of Obsessive-compulsive Disorder: Is it Time for the Concept of an “Autoimmune OCD” subtype?

A conceptual review of considering frequent primary OCD and secondary rare organic forms of OCD with a structured clinical approach. Autoimmune OCDs red flag signs for “autoimmune OCD” could include (sub)acute onset, unusual age of onset, atypical presentation of OCS with neuropsychiatric features (e.g., disproportionate cognitive deficits) or accompanying neurological symptoms (e.g., movement disorders), autonomic… Continue reading Immunological Causes of Obsessive-compulsive Disorder: Is it Time for the Concept of an “Autoimmune OCD” subtype?

Research Finds the Stress Circuit in Brain that Affects Memory, Fight or Flight, and More

RESEARCH FINDS THE STRESS CIRCUIT in Brain that Affects Memory, Fight or Flight, Logic, Inhibition Controls, etc P/P IS EXACERBATED by STRESS.U OF IOWA: MEDIAL PREFRONTAL CORTEX (PFC) is AFFECTED BY STRESS: This area regulates a lot of the PANDAS Symptoms such as focused attention, habits (OCD), memory, inhibition controls, fight or flight, memory. Read the… Continue reading Research Finds the Stress Circuit in Brain that Affects Memory, Fight or Flight, and More